12/29/2023 0 Comments Inetwork communications dony tran![]() ![]() This new arena of antibiotics encompasses a plethora of nanostructured pathogen fighters, such as nanocarriers loaded with antibiotics 3, metal 4, 5 or metal oxide nanoparticles 6, 7, organic–inorganic composite nanoparticles 8, 9, 10, graphene or graphene oxide 11, 12, 13, carbon nanotubes 14, dendrimers 15, self-assembled micelles 16, unimolecular micelles 17, supramolecular nanostructures 18, 19, and polymer molecular brushes (i.e., bottlebrush polymers) 20, 21, 22, 23. This study illuminates nanoengineering as a viable approach to develop nanoantibiotics that kill bacteria upon contact yet remain nontoxic when engulfed by mammalian cells.Īntibacterial nanomaterials, or nanoantibiotics, are emerging contenders to fend off drug-resistant bacteria when conventional antibiotics fail 1, 2. We identify a threshold size (d silica ~ 50 nm) only beneath which NPPBs remodel bacteria-mimicking membrane into 2D columnar phase, the epitome of membrane pore formation. The acquired antimicrobial potency intensifies with small nanoparticles but subsides quickly with large ones. Assembly of the hydrophilic polymers into nanostructured NPPBs doesn’t alter their amicability with mammalian cells, but it incurs a transformation of their antimicrobial potential against bacteria, including clinical multidrug-resistant strains, that depends critically on the nanoparticle sizes. To dissect the antibiotic role of nanostructures from chemical moieties belligerent to both bacterial and mammalian cells, here we show the antimicrobial activity and cytotoxicity of nanoparticle-pinched polymer brushes (NPPBs) consisting of chemically inert silica nanospheres of systematically varied diameters covalently grafted with hydrophilic polymer brushes that are non-toxic and non-bactericidal.
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